One-pot preparation of piperazines by regioselective ring-opening of non-activated arylaziridines.
نویسندگان
چکیده
Herein we report a new straightforward synthesis of cis and trans 2,5-disubstituted N,N-dialkylpiperazines, even in enantioenriched form, by reacting non-activated N-alkyl arylaziridines in the presence of a catalytic amount of a Lewis acid. A stereochemical and NMR investigation revealed useful mechanistic insights for this process.
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ورودعنوان ژورنال:
- Organic & biomolecular chemistry
دوره 10 10 شماره
صفحات -
تاریخ انتشار 2012